Rheumatoid arthritis diagnosis criteria 2015

In the late twentieth century, rheumatoid arthritis was recognized as an autoimmune disease primarily characterized by polyarthritis. However, disease control was inadequate, and the progression of joint destruction could not be prevented. This resulted in the use of glucocorticoids and non-steroidal anti-inflammatory drugs for the treatment of rheumatoid arthritis in the twentieth century to alleviate pain and swelling. He was awarded the Nobel Prize in Physiology or Medicine in 1950. Hench reported the first administration of cortisone to patients with rheumatoid arthritis, and its dramatic effect was widely recognized. In 1853, Gerhardt first synthesized acetylsalicylic acid, which had superior in vivo stability to salicin, and in 1897, acetylsalicylic acid was marketed as a tablet for arthralgia by Hoffmann in Bayer and is now used other conditions worldwide. In the nineteenth century, salicin was discovered as a component of the bark. There is a 2500-year-old record stating that drinking a decoction of European white willow bark alleviates pain. This disease has afflicted humanity for a long period of time, and its treatment also has a long history. The term rheumatism comes from the 2500-year-old Greek word meaning вЂњflowing current,вЂќ indicating the flow of the affected joints in the entire body. Thus, proper diagnosis and treatment are required in the early stages of the disease. Joint destruction progresses rapidly after onset, resulting in irreversible physical dysfunction and deformation of the affected joints. It is accompanied by multi-organ disorders, in addition to pain, swelling, and stiffness of multiple joints. It commonly affects women in their 30s to 50s, with an incidence of 1 in 150. Rheumatoid arthritis is an autoimmune inflammatory disease primarily characterized by synovitis. In the future, safer and more effective treatments, therapeutic strategies aimed at drug holidays or cure, and the introduction of precision medicine are expected.

The advent of molecular-targeted therapies has allowed for the use of treatments based on pathological mechanisms, and such therapeutic strategies have also been applied to the treatment of various autoimmune inflammatory diseases. By maintaining remission, these drugs have also been shown to prevent the progression of joint destruction and physical dysfunction over a long period. The appropriate use of these drugs has allowed remission to be the therapeutic goal in all patients. DMARDs are classified into different groups, such as conventional synthetic DMARD, targeted synthetic DMARD, and biologic DMARD. Although palliative therapy with glucocorticoids and anti-inflammatory drugs hadВ beenВ used, disease-modifying antirheumatic drugs (DMARDs) are currently used to suppress immune abnormalities and to control disease activity. Thus, proper diagnosis and treatment are required from the early stages of the disease. Joint destruction progresses soon after the onset, and once the affected joints are deformed, the development of irreversible physical dysfunction is noted. Rheumatoid arthritis is an autoimmune inflammatory disease primarily characterized by synovitis which is accompanied by extra-articular organ involvement, such as interstitial pneumonia, in addition to clinical symptoms including pain, swelling, stiffness of multiple joints, fever, and malaise.

Rheumatoid arthritis diagnosis criteria 2015